Articles
The importance of environmental influences on pediatric asthma initiation and prevention
ABSTRACT
Complex interactions involving human genes, the immune system, and certain environmental factors may lead to asthma. The type and severity of airway inflammation and remodeling, as well as the asthma phenotype, are primarily determined by these interactions. Furthermore, it has been shown that exposure to environmental factors may either initiate asthma in those who are genetically predisposed, or de novo generate it in people who do not have a genetic background. This review examines the importance of the environment in asthma onset and prevention and delineates the possible mechanistic pathways underlying this effect.
IMPACT STATEMENT
This article describes the importance of gene-environmental interactions in asthma onset and persistence, and underpins the significance of epigenetics as a tool to modify asthma natural course.
Received: July 1, 2024
Accepted: July 11, 2024
Published: Sept 01, 2024
