Translational medicine and omic sciences in pediatric pulmonology

ABSTRACT
During the past two decades omic technologies have been gaining importance in the field of complex non-communicable diseases. Asthma is a condition particularly suited to be studied with this approach since it is a multifactorial disease resulting from a complex interplay between genetic, biological, and environmental factors.
Aim of our narrative review is to summarize the findings of the most recent literature on the application of omic technologies in the study of asthma in children.
The identified studies belong to two main research areas: the first concerns the prediction of recurrent wheezing/asthma development; the second concerns the assessment of children with asthma to study the molecular mechanisms underlying relevant clinical features of the disease and to search for biomarkers predictive of treatment response. The identified studies show the potential of omic platforms but also the need of integrating omic and clinical data in the view of possible clinical applications in a near future.

IMPACT STATEMENT
Our narrative review provides a general overview on the main findings of the most recent studies that have applied a omic approach in the study of pediatric asthma.

Received: Jan 26, 2023
Accepted: Apr 29, 2023
Published: June 1, 2023